Correlation between the arthritis score and Bv8 mRNA expression. One group consisted of 5 mice. b shows the results of analysis by RT-PCR. c and d show the results of analysis by real-time PCR. The relative expression of Bv8 and VEGF mRNA was standardized to that of GAPDH mRNA. The results are expressed relative to day 21 CIA mice, arbitrarily assigned a value of 1.0. a. Changes in the arthritis score. b. Comparison of Bv8 mRNA expression in joint tissue on day 28 between the CIA and control groups. c. Bv8 mRNA expression in arthritic joints on days 21, 24, 28, and 35. d. VEGF mRNA expression in arthritic joints on days 21, 24, 28, and 35.