Point mutation of tyrosine 759 of the IL-6 family cytokine receptor, gp130, augments collagen-induced arthritis in DBA/1J mice

Table 4 Methotrexate attenuated CIA in gp130F759 mice (male, histopathological analysis)

Day 42		Vehicle	MTX
	Grade	24*	22*
Proliferation of the synovial lining cells	0	7	16
	1	0	0
	2	12	3
	3	5	3
	4	0	0
Destruction of the articular cartilage/bone	0	6	16
	1	0	0
	2	3	2
	3	15	4
	4	0	0
Inflammatory cell infiltration, rich in neutrophils	0	5	15
	1	0	0
	2	4	1
	3	11	6
	4	4	0

All data refer to the number of limbs with the finding in the group.
*Total number of limbs in the group
Grade of change: 0, negative; 1, very slight; 2, slight; 3, moderate; 4, severe.

ISSN: 1471-2474