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Table 3 Destructive arthritis developed in CIA in DBA/1J gp130F759 mice

From: Point mutation of tyrosine 759 of the IL-6 family cytokine receptor, gp130, augments collagen-induced arthritis in DBA/1J mice

Day 56

 

Male

Female

  

Wlid

F759

Wild

F759

 

Grade

20*

16*

20*

14*

Proliferation of the synovial lining cells

0

7

0

8

1

 

1

1

1

4

0

 

2

3

3

2

1

 

3

7

10

4

11

 

4

2

2

2

1

Destruction of the articular cartilage/bone

0

9

3

14

1

 

1

0

0

1

0

 

2

4

0

2

0

 

3

7

8

2

13

 

4

0

5

1

0

Inflammatory cell infiltration, rich in neutrophils

0

10

3

12

1

 

1

1

0

2

1

 

2

1

11

2

6

 

3

5

2

3

5

 

4

3

0

1

1

  1. All data refer to the number of limbs with the finding in the group.
  2. *Total number of limbs in the group
  3. Grade of change: 0, negative; 1, very slight; 2, slight; 3, moderate; 4, severe.
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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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