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Table 1 Histopathological analysis of gp130F759 mice (12 months) Male

From: Point mutation of tyrosine 759 of the IL-6 family cytokine receptor, gp130, augments collagen-induced arthritis in DBA/1J mice

 

C57BL/6

DBA/1J

Findings

Wild

F759

Wild

F759

Joint (lower extremity); Synovial cell proliferation

0/5

5/5

0/5

0/5

Kidney; Glomerulonephritis

0/5

0/5

0/5

0/5

Eye; Keratitis

0/5

0/5

1/5

4/5

Lung; Cellular infiltration

0/5

5/5

0/5

3/5

Spleen; Hyperplasia, plasma cell

0/5

5/5

0/5

0/5

Thymus; Hypertrophy/hyperplasia, medulla

0/5

5/5

0/5

2/5

Lymph node (mesenteric); Hyperplasia, plasma cell

0/5

4/5

0/5

0/5