Figure 8From: Point mutation of tyrosine 759 of the IL-6 family cytokine receptor, gp130, augments collagen-induced arthritis in DBA/1J mice Methotrexate attenuated CIA (a), and delayed the onset of arthritis (b) in gp130F759 mice (male). Values are expressed as mean ± standard error of 11 to 12 animals. *P < 0.05, **P < 0.01 versus vehicle-treated group by Student's t-test. a P < 0.05, aa P < 0.01 versus Non-immunized group by Student's t-test.Back to article page