Predicted recognition sequences for miR-140 and miR-27a in the 3'-UTR of the MMP-13 and IGFBP-5 mRNAs. The 3'-UTRs were analyzed by computational programs to predict the presence of functional miR-140 and miR-27a sites. (A) Schematic representation of the mRNAs; ORF (open reading frame), ATG (start codon), TAA and TGA (stop codons), bp (base pair). The numbering starts at the first base following the stop codon. The arrows indicate the location of the potential pairing sites for the miRNAs. (B) Sequences of the potential pairing sites for miR-27a and miR-140. The bars indicate base pair homology.