Cartilage
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Two step process for each joint surface:
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Cartilage signal summarized as:
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1. Grade degree of cartilage damage:
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0-None = normal
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0 = Normal
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1-Mild = heterogeneity or fraying
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1 = Increased signal heterogeneity without surface disruption
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2-Moderate = fissuring or thinning < 50%
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2 = Fraying (superficial only)
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3-Severe = thinning > 50% or full thickness
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3 = Fissuring (full thickness lesions <1 mm in width)
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Lesion size summarized as:
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4 = Thinning <50% cartilage thickness
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0-None = normal
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5 = Thinning >50% cartilage thickness
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1-Mild = < 1 cm
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6 = Full thickness cartilage loss
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2-Moderate = 1-2 cm
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2. Score greatest diameter of greatest severity lesion
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3-Severe = > 2 cm
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0 = Normal
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Cartilage signal and lesion size scores summed over 17 regions to give hypothetical range 0-102.
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1 = <1 cm
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None = 0
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2 = 1-2 cm
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Mild = 1-30
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3 = 2-3 cm
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Moderate = 30-60
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4 = >3 cm
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Severe = > 60
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Osteophytes
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Two step process for each joint compartment:
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Compartmental scores (medial, lateral, patellofemoral) were summed for the whole knee. The possible score range was 0-9. Final assessment of osteophytosis:
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1. Grade individual osteophytes according to the size of the greatest dimension:
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None = 0
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0 = <1 mm
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Mild = 1-3
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1 = 1-2 mm
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Moderate = 4-5
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2 = 2-5 mm
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Severe = 6+
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3 = >5 mm
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2. Sum scores of all individual osteophytes to give compartmental score:
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0 = normal individual sum 0
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1 = mild individual sum 1-2
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2 = moderate individual sum 3-4
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3 = severe individual sum >4
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Bone Marrow Lesions
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Greatest diameter of each lesion recorded for both femoral and tibial surfaces as well as the patellofemoral compartment:
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Scores for patellofemoral compartment and femoral and tibial surfaces were summed. The possible score range was 0-15. Final assessment of bone marrow lesions:
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0 = None
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None = 0
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1 = Mild (<0.5 cm)
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Mild = 1-3
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2 = Moderate (0.5-1.5 cm)
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Moderate = 4-5
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3 = Severe (>1.5 cm)
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Severe = 6+
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Effusion
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Greatest diameter of the effusion perpendicular to the long-axis of the leg:
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Effusion was recorded as a single score for the whole knee. No changes were made for final analysis.
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0 = None (0.0-0.5 cm fluid)
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1 = Mild (0.5 -- 1.0 cm fluid)
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2 = Moderate (1.0 -- 2.0 cm fluid)
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3 = Severe (>2.0 cm fluid)
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Synovitis
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Assessed by counting the number of thickened villi seen on T2-weighted sequences
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Synovitis was recorded as a single score for the whole knee. No changes were made for final analysis.
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0 = None (<5 villi seen, all normal thickness)
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1 = Mild (6-10 villi seen, some thickened)
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2 = Moderate (11-15 villi seen, mostly thickened)
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3 = Severe (> 15 villi seen, marked thickening)
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Subchondral Sclerosis
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For each compartment:
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Final score determined by number of the 3 knee compartments with evidence of sclerotic change
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0 = Absent
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0 = Absent
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1 = Present
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1 = Mild
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2 = Moderate
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3 = Severe
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