Figure 1

Relationships between the improvements in temperature and pain in the ISDN and Tadalafil studies. The improvement in pain is shown on the horizontal axis. The Visual Analogue Scale (VAS, score 0-100) is the average of actual pain scores that were recorded three times each day (0800, 1200 and 2000) during one week before the first and the last hospital visits. The improvement in pain is calculated by subtracting the VAS score at the end of the study from the VAS score at the start of the study; thus, a positive value indicates less pain. The vertical axis shows the changes in temperature calculated by subtracting the temperature difference (CRPS side minus contralateral side) between the dorsal side of both hands at the end of the study from the difference measured at the start of the study. A positive value indicates that the difference in temperature has diminished.