Pathophysiology of musculoskeletal disorders

Section edited by Ali Mobasheri

This section concerns all aspects of the pathophysiology of musculoskeletal disorders.

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  1. Research article

    Altered somatosensory profile according to quantitative sensory testing in patients with degenerative lumbar spine disorders scheduled for surgery

    Somatosensory profiling in affected and non-affected body regions can strengthen our insight regarding the underlying pain mechanisms, which can be valuable in treatment decision making and to improve outcomes...

    Yvonne Lindbäck, Hans Tropp, Paul Enthoven, Björn Gerdle, Allan Abbott and Birgitta Öberg

    BMC Musculoskeletal Disorders 2017 18:264

    Published on: 17 June 2017

  2. Research article

    The mitochondrial inhibitor oligomycin induces an inflammatory response in the rat knee joint

    Recent findings support a connection between mitochondrial dysfunction and activation of inflammatory pathways in articular cells. This study investigates in vivo in an acute model whether intra-articular admi...

    Carlos Vaamonde-García, Jesús Loureiro, Marta N. Valcárcel-Ares, Romina R. Riveiro-Naveira, Olalla Ramil-Gómez, Laura Hermida-Carballo, Alberto Centeno, Rosa Meijide-Failde, Francisco J. Blanco and María J. López-Armada

    BMC Musculoskeletal Disorders 2017 18:254

    Published on: 12 June 2017

  3. Research article

    Factors influencing treatment success of negative pressure wound therapy in patients with postoperative infections after Osteosynthetic fracture fixation

    Negative Pressure Wound Therapy (NPWT) is being increasingly used to treat postoperative infections after osteosynthetic fracture fixation. The aim of the present study was to analyze the influence of epidemio...

    Kaywan Izadpanah, Stephanie Hansen, Julia Six-Merker, Peter Helwig, Norbert P Südkamp and Hagen Schmal

    BMC Musculoskeletal Disorders 2017 18:247

    Published on: 7 June 2017

  4. Research article

    Early anti-inflammatory intervention ameliorates axial disease in the proteoglycan-induced spondylitis mouse model of ankylosing spondylitis

    Ankylosing spondylitis (AS) is characterised by immune-mediated arthritis and osteoproliferation, ultimately leading to joint ankylosis. Whether inflammation is necessary for osteoproliferation is controversia...

    Hsu-Wen Tseng, Tibor T. Glant, Matthew A. Brown, Tony J. Kenna, Gethin P. Thomas and Allison R. Pettit

    BMC Musculoskeletal Disorders 2017 18:228

    Published on: 30 May 2017

  5. Research article

    Glutamate signaling through the NMDA receptor reduces the expression of scleraxis in plantaris tendon derived cells

    A body of evidence demonstrating changes to the glutaminergic system in tendinopathy has recently emerged. This hypothesis was further tested by studying the effects of glutamate on the tenocyte phenotype, and...

    Christoph Spang, Ludvig J. Backman, Sandrine Le Roux, Jialin Chen and Patrik Danielson

    BMC Musculoskeletal Disorders 2017 18:218

    Published on: 25 May 2017

  6. Research article

    Immunogenicity and immunomodulatory effects of the human chondrocytes, hChonJ

    Invossa™ (TissueGene-C) is a cell and gene therapy for osteoarthritis. It is composed of primary human chondrocytes (hChonJ cells) and irradiated human chondrocytes modified to express TGF-β1 (hChonJb#7 cells)...

    Chae-Lyul Lim, Yeon-Ju Lee, Jong-Ho Cho, Heonsik Choi, Bumsup Lee, Myung Chul Lee and Sujeong Kim

    BMC Musculoskeletal Disorders 2017 18:199

    Published on: 18 May 2017

  7. Research article

    Mucin 1, a signal transduction membrane-bound mucin, is present in human disc tissue and is downregulated in vitro by exposure to IL-1ß or TNF-α

    Back pain and disc degeneration have a growing socioeconomic healthcare impact. Mucin 1 (MUC1) is a transmembrane glycoprotein whose extracellular and intracellular domains participate in cellular signaling. L...

    Helen E. Gruber, Jane A. Ingram, Gretchen L. Hoelscher, Emilio Marrero and Edward N. Hanley

    BMC Musculoskeletal Disorders 2017 18:182

    Published on: 8 May 2017

  8. Research article

    Return to sports after plate fixation of humeral head fractures 65 cases with minimum 24-month follow-up

    Humeral head fractures requiring surgical intervention are severe injuries, which might affect the return to sports and daily activities. We hypothesize that athletic patients will be constrained regarding the...

    Philipp Ahrens, Frank Martetschläger, Sebastian Siebenlist, Johann Attenberger, Moritz Crönlein, Peter Biberthaler, Ulrich Stöckle and Gunther H. Sandmann

    BMC Musculoskeletal Disorders 2017 18:173

    Published on: 26 April 2017

  9. Technical advance

    Gait characterization in golden retriever muscular dystrophy dogs using linear discriminant analysis

    Accelerometric analysis of gait abnormalities in golden retriever muscular dystrophy (GRMD) dogs is of limited sensitivity, and produces highly complex data. The use of discriminant analysis may enable simpler...

    Bodvaël Fraysse, Inès Barthélémy, El Mostafa Qannari, Karl Rouger, Chantal Thorin, Stéphane Blot, Caroline Le Guiner, Yan Chérel and Jean-Yves Hogrel

    BMC Musculoskeletal Disorders 2017 18:153

    Published on: 12 April 2017

  10. Research article

    Fat in the lumbar multifidus muscles - predictive value and change following disc prosthesis surgery and multidisciplinary rehabilitation in patients with chronic low back pain and degenerative disc: 2-year follow-up of a randomized trial

    Evidence is lacking on whether fat infiltration in the multifidus muscles affects outcomes after total disc replacement (TDR) surgery and if it develops after surgery. The aims of this study were 1) to investi...

    Kjersti Storheim, Linda Berg, Christian Hellum, Øivind Gjertsen, Gesche Neckelmann, Ansgar Espeland and Anne Keller

    BMC Musculoskeletal Disorders 2017 18:145

    Published on: 4 April 2017

  11. Research article

    Hepatocytes express the antimicrobial peptide HBD-2 after multiple trauma: an experimental study in human and mice

    Human-beta defensins (HBD) belong to the family of acute phase peptides and hold a broad antimicrobial spectrum that includes gram-positive and gram-negative bacteria. HBD are up-regulated after severe injurie...

    Stefanie Fitschen-Oestern, Matthias Weuster, Sebastian Lippross, Peter Behrendt, Sabine Fuchs, Thomas Pufe, Mersedeh Tohidnezhad, Andreas Bayer, Andreas Seekamp, Deike Varoga and Tim Klüter

    BMC Musculoskeletal Disorders 2017 18:100

    Published on: 7 March 2017

  12. Case report

    A rare case of multiple phosphaturic mesenchymal tumors along a tendon sheath inducing osteomalacia

    Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by renal phosphate wasting, hypophosphatemia, reduction of 1,25-dihydroxyl vitamin D, and bone calcification disorders. Tumors a...

    Ryuta Arai, Tomohiro Onodera, Mohamad Alaa Terkawi, Tomoko Mitsuhashi, Eiji Kondo and Norimasa Iwasaki

    BMC Musculoskeletal Disorders 2017 18:79

    Published on: 13 February 2017

  13. Research article

    Strontium ranelate causes osteophytes overgrowth in a model of early phase osteoarthritis

    Osteoarthritis (OA) involves cartilage changes as well as modifications of subchondral bone and synovial tissues. Strontium ranelate (SR), an anti-osteoporosis compound, which is currently in phase III clinica...

    Jian-Guo Chu, Mu-Wei Dai, Yu Wang, Fa-Ming Tian, Hui-Ping Song, Ya-Ping Xiao, Li-Tao Shao, Ying-Ze Zhang and Liu Zhang

    BMC Musculoskeletal Disorders 2017 18:78

    Published on: 10 February 2017

  14. Research article

    Agonist muscle adaptation accompanied by antagonist muscle atrophy in the hindlimb of mice following stretch-shortening contraction training

    The vast majority of dynamometer-based animal models for investigation of the response to chronic muscle contraction exposure has been limited to analysis of isometric, lengthening, or shortening contractions ...

    Erik P. Rader, Marshall A. Naimo, James Ensey and Brent A. Baker

    BMC Musculoskeletal Disorders 2017 18:60

    Published on: 2 February 2017

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