Pathophysiology of musculoskeletal disorders

Section edited by Ali Mobasheri

This section concerns all aspects of the pathophysiology of musculoskeletal disorders.

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  1. Research article

    Return to sports after plate fixation of humeral head fractures 65 cases with minimum 24-month follow-up

    Humeral head fractures requiring surgical intervention are severe injuries, which might affect the return to sports and daily activities. We hypothesize that athletic patients will be constrained regarding the...

    Philipp Ahrens, Frank Martetschläger, Sebastian Siebenlist, Johann Attenberger, Moritz Crönlein, Peter Biberthaler, Ulrich Stöckle and Gunther H. Sandmann

    BMC Musculoskeletal Disorders 2017 18:173

    Published on: 26 April 2017

  2. Technical advance

    Gait characterization in golden retriever muscular dystrophy dogs using linear discriminant analysis

    Accelerometric analysis of gait abnormalities in golden retriever muscular dystrophy (GRMD) dogs is of limited sensitivity, and produces highly complex data. The use of discriminant analysis may enable simpler...

    Bodvaël Fraysse, Inès Barthélémy, El Mostafa Qannari, Karl Rouger, Chantal Thorin, Stéphane Blot, Caroline Le Guiner, Yan Chérel and Jean-Yves Hogrel

    BMC Musculoskeletal Disorders 2017 18:153

    Published on: 12 April 2017

  3. Research article

    Fat in the lumbar multifidus muscles - predictive value and change following disc prosthesis surgery and multidisciplinary rehabilitation in patients with chronic low back pain and degenerative disc: 2-year follow-up of a randomized trial

    Evidence is lacking on whether fat infiltration in the multifidus muscles affects outcomes after total disc replacement (TDR) surgery and if it develops after surgery. The aims of this study were 1) to investi...

    Kjersti Storheim, Linda Berg, Christian Hellum, Øivind Gjertsen, Gesche Neckelmann, Ansgar Espeland and Anne Keller

    BMC Musculoskeletal Disorders 2017 18:145

    Published on: 4 April 2017

  4. Research article

    Hepatocytes express the antimicrobial peptide HBD-2 after multiple trauma: an experimental study in human and mice

    Human-beta defensins (HBD) belong to the family of acute phase peptides and hold a broad antimicrobial spectrum that includes gram-positive and gram-negative bacteria. HBD are up-regulated after severe injurie...

    Stefanie Fitschen-Oestern, Matthias Weuster, Sebastian Lippross, Peter Behrendt, Sabine Fuchs, Thomas Pufe, Mersedeh Tohidnezhad, Andreas Bayer, Andreas Seekamp, Deike Varoga and Tim Klüter

    BMC Musculoskeletal Disorders 2017 18:100

    Published on: 7 March 2017

  5. Case report

    A rare case of multiple phosphaturic mesenchymal tumors along a tendon sheath inducing osteomalacia

    Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by renal phosphate wasting, hypophosphatemia, reduction of 1,25-dihydroxyl vitamin D, and bone calcification disorders. Tumors a...

    Ryuta Arai, Tomohiro Onodera, Mohamad Alaa Terkawi, Tomoko Mitsuhashi, Eiji Kondo and Norimasa Iwasaki

    BMC Musculoskeletal Disorders 2017 18:79

    Published on: 13 February 2017

  6. Research article

    Strontium ranelate causes osteophytes overgrowth in a model of early phase osteoarthritis

    Osteoarthritis (OA) involves cartilage changes as well as modifications of subchondral bone and synovial tissues. Strontium ranelate (SR), an anti-osteoporosis compound, which is currently in phase III clinica...

    Jian-Guo Chu, Mu-Wei Dai, Yu Wang, Fa-Ming Tian, Hui-Ping Song, Ya-Ping Xiao, Li-Tao Shao, Ying-Ze Zhang and Liu Zhang

    BMC Musculoskeletal Disorders 2017 18:78

    Published on: 10 February 2017

  7. Research article

    Agonist muscle adaptation accompanied by antagonist muscle atrophy in the hindlimb of mice following stretch-shortening contraction training

    The vast majority of dynamometer-based animal models for investigation of the response to chronic muscle contraction exposure has been limited to analysis of isometric, lengthening, or shortening contractions ...

    Erik P. Rader, Marshall A. Naimo, James Ensey and Brent A. Baker

    BMC Musculoskeletal Disorders 2017 18:60

    Published on: 2 February 2017

  8. Research article

    Pigment Epithelium-Derived Factor (PEDF) mediates cartilage matrix loss in an age-dependent manner under inflammatory conditions

    Inflammation is a major cause of cartilage destruction and leads to the imbalance of metabolic activities in the arthritic joint. Pigment epithelium-derived factor (PEDF) has been reported to have both pro- an...

    Daisy S. Nakamura, Judith M. Hollander, Tomoya Uchimura, Heber C. Nielsen and Li Zeng

    BMC Musculoskeletal Disorders 2017 18:39

    Published on: 25 January 2017

  9. Research article

    Treatment with soluble activin type IIB-receptor improves bone mass and strength in a mouse model of Duchenne muscular dystrophy

    Inhibition of activin/myostatin pathway has emerged as a novel approach to increase muscle mass and bone strength. Duchenne muscular dystrophy (DMD) is a neuromuscular disorder that leads to progressive muscle...

    Tero Puolakkainen, Hongqian Ma, Heikki Kainulainen, Arja Pasternack, Timo Rantalainen, Olli Ritvos, Kristiina Heikinheimo, Juha J. Hulmi and Riku Kiviranta

    BMC Musculoskeletal Disorders 2017 18:20

    Published on: 19 January 2017

  10. Research article

    Cytokine and neuropeptide levels are associated with pain relief in patients with chronically painful total knee arthroplasty: a pilot study

    There are few studies with an assessment of the levels of cytokines or neuropeptides as correlates of pain and pain relief in patients with painful joint diseases. Our objective was to assess whether improveme...

    Jasvinder A. Singh, Siamak Noorbaloochi and Keith L. Knutson

    BMC Musculoskeletal Disorders 2017 18:17

    Published on: 14 January 2017

  11. Research article

    Correlation between lumbar dysfunction and fat infiltration in lumbar multifidus muscles in patients with low back pain

    Lumbar multifidus muscles (LMM) are important for spinal motion and stability. Low back pain (LBP) is often associated with fat infiltration in LMM. An increasing fat infiltration of LMM may lead to lumbar dys...

    Markus Hildebrandt, Gabriela Fankhauser, André Meichtry and Hannu Luomajoki

    BMC Musculoskeletal Disorders 2017 18:12

    Published on: 10 January 2017

  12. Research article

    Genes associated with persistent lumbar radicular pain; a systematic review

    The aim of the present study was to provide an overview of the literature addressing the role of genetic factors and biomarkers predicting pain recovery in newly diagnosed lumbar radicular pain (LRP) patients.

    Siri Bjorland, Aurora Moen, Elina Schistad, Johannes Gjerstad and Cecilie Røe

    BMC Musculoskeletal Disorders 2016 17:500

    Published on: 13 December 2016

  13. Research article

    Proarrhythmic risk and determinants of cardiac autonomic dysfunction in collagen-induced arthritis rats

    Patients with rheumatoid arthritis (RA) have increased risk of sudden cardiac death (SCD), which is two-fold higher than general population. The driving cause of SCD was considered due to lift-threatening arrh...

    Ting-Tse Lin, Yen-Ling Sung, Chih-En Wu, Hong Zhang, Yen-Bin Liu and Shien-Fong Lin

    BMC Musculoskeletal Disorders 2016 17:491

    Published on: 29 November 2016

  14. Research article

    Are persons with fibromyalgia or other musculoskeletal pain more likely to report hearing loss? A HUNT study

    Leading theories about the pathogenesis of fibromyalgia focus on central nervous dysregulation or sensitization, which can cause altered perception. There is growing evidence that fibromyalgia involves altered...

    Magne Stranden, Håvard Solvin, Egil A. Fors, Linn Getz and Anne-S. Helvik

    BMC Musculoskeletal Disorders 2016 17:477

    Published on: 16 November 2016

  15. Research article

    Anti-fibrotic action of pirfenidone in Dupuytren’s disease-derived fibroblasts

    Dupuytren’s disease (DD) is a complex fibro-proliferative disorder of the hand that is often progressive and eventually can cause contractures of the affected fingers. Transforming growth factor beta (TGF-β1) has...

    Chaoming Zhou, Fang Liu, Phillip H. Gallo, Mark E. Baratz, Sandeep Kathju and Latha Satish

    BMC Musculoskeletal Disorders 2016 17:469

    Published on: 11 November 2016

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