Clinical rheumatology and osteoporosis

Section edited by Jasvinder Singh

This section concerns all aspects of research into osteoporosis and rheumatic diseases, where the primary focus relates specifically to a component(s) of the musculoskeletal system

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  1. Research article

    Antiresorptive effect of a cathepsin K inhibitor ONO-5334 and its relationship to BMD increase in a phase II trial for postmenopausal osteoporosis

    ONO-5334 is a cathepsin K inhibitor that induced bone mineral density (BMD) gain in a phase II study in postmenopausal osteoporosis patients. Even though the antiresorptive effect could only be monitored in th...

    Makoto Tanaka, Yoshitaka Hashimoto, Chihiro Hasegawa, Steve Deacon and Richard Eastell

    BMC Musculoskeletal Disorders 2017 18:267

    Published on: 19 June 2017

  2. Research article

    The pathway to consultation for rheumatoid arthritis: exploring anticipated actions between the onset of symptoms and face-to-face encounter with a healthcare professional

    When people first experience symptoms of rheumatoid arthritis (RA) they often delay seeking medical attention resulting in delayed diagnosis and treatment. This research assesses behaviours people might engage...

    Gwenda Simons, Sophie Lumley, Marie Falahee, Kanta Kumar, Christian D. Mallen, Rebecca J. Stack and Karim Raza

    BMC Musculoskeletal Disorders 2017 18:258

    Published on: 14 June 2017

  3. Research article

    Validity of the Nurses’ health study physical activity questionnaire in estimating physical activity in adults with rheumatoid arthritis

    Patients with rheumatoid arthritis (RA) demonstrate reduced aerobic capacity, excess cardiovascular risk, mobility limitations and are less physically active than their healthy peers. Physical activity may dec...

    Thomas Quinn, Michelle Frits BS, Johan von Heideken, Christine Iannaccone, Nancy A. Shadick, Michael Weinblatt and Maura D. Iversen

    BMC Musculoskeletal Disorders 2017 18:234

    Published on: 31 May 2017

  4. Research article

    Patients’ views and needs about systemic sclerosis and its management: a qualitative interview study

    Systemic sclerosis (SSc) is a chronic connective-tissue disease responsible for reduced life expectancy, disability and a decreased quality of life. In order to optimize patients-physicians relationship and ca...

    Luc Mouthon, Sophie Alami, Anne-Sophie Boisard, Benjamin Chaigne, Eric Hachulla and Serge Poiraudeau

    BMC Musculoskeletal Disorders 2017 18:230

    Published on: 30 May 2017

  5. Research article

    Reduction of the Serum Levels of a Specific Biomarker of Cartilage Degradation (Coll2-1) by Hyaluronic Acid (KARTILAGE® CROSS) Compared to Placebo in Painful Knee Osteoarthritis Patients: the EPIKART Study, a Pilot Prospective Comparative Randomized Double Blind Trial

    Viscosupplementation is a symptomatic treatment of the knee osteoarthritis based on the intra-articular injection of hyaluronic acid (IAHA). Although many studies have investigated its effect on symptoms, few ...

    Yves Henrotin, Francis Berenbaum, Xavier Chevalier, Marc Marty, Pascal Richette and François Rannou

    BMC Musculoskeletal Disorders 2017 18:222

    Published on: 26 May 2017

  6. Research article

    Association between antibodies to carbamylated proteins and subclinical atherosclerosis in rheumatoid arthritis patients

    Rheumatoid arthritis (RA) patients carry a high risk of cardiovascular morbidity and mortality. The excess of cardiovascular disease cannot be entirely explained by traditional risk factors and the immune syst...

    Francesca Romana Spinelli, Arbi Pecani, Francesco Ciciarello, Tania Colasanti, Manuela Di Franco, Francesca Miranda, Fabrizio Conti, Guido Valesini and Cristiano Alessandri

    BMC Musculoskeletal Disorders 2017 18:214

    Published on: 25 May 2017

    The Erratum to this article has been published in BMC Musculoskeletal Disorders 2017 18:263

  7. Research article

    Factors associated with hand joint destruction in Chinese patients with rheumatoid arthritis

    There have been no previous report of hand joint destruction prevalence in Chinese rheumatoid arthritis (RA) patients. Therefore, the aim of this study was to investigate the prevalence and potential factors o...

    Lijuan Zhang, Jing Wang, Qiuxiang Zhang, Ting Fu, Rulan Yin, Ze Wang, Liren Li, Xianhua Wu and Zhifeng Gu

    BMC Musculoskeletal Disorders 2017 18:211

    Published on: 22 May 2017

    The Erratum to this article has been published in BMC Musculoskeletal Disorders 2017 18:231

  8. Research article

    Multidimensional daily diary of fatigue-fibromyalgia-17 items (MDF-fibro-17): part 2 psychometric evaluation in fibromyalgia patients

    The Multidimensional Daily Diary of Fatigue-Fibromyalgia-17 instrument (MDF-Fibro-17) has been developed for use in fibromyalgia (FM) clinical studies and includes 5 domains: Global Fatigue Experience, Cogniti...

    Y. Li, S. Morris, J. Cole, S. Dube’, J. A. M. Smith, C. Burbridge, T. Symonds, S. Hudgens and W. Wang

    BMC Musculoskeletal Disorders 2017 18:198

    Published on: 18 May 2017

  9. Research article

    Multidimensional daily diary of fatigue–fibromyalgia–17 items (MDF-fibro-17). part 1: development and content validity

    Fibromyalgia (FM), a disorder characterized by chronic widespread pain and tenderness, affects greater than five million individuals in the United States alone. Patients experience multiple symptoms in additio...

    S. Morris, Y. Li, J.A.M. Smith, S. Dube’, C. Burbridge and T. Symonds

    BMC Musculoskeletal Disorders 2017 18:195

    Published on: 16 May 2017

  10. Research article

    Persons with rheumatoid arthritis challenge the relevance of the health assessment questionnaire: a qualitative study of patient perception

    The Stanford Health Assessment Questionnaire-Disability Index (HAQ) is widely used to measure functional ability in persons with Rheumatoid Arthritis (RA). The instrument was developed with limited involvement...

    David Ebbevi, Anna Essén and Helena Hvitfeldt Forsberg

    BMC Musculoskeletal Disorders 2017 18:189

    Published on: 12 May 2017

  11. Research article

    Influence of subject discontinuation on long-term nonvertebral fracture rate in the denosumab FREEDOM Extension study

    Denosumab treatment for up to 8 years in the FREEDOM study and Extension was associated with low fracture incidence. It was not clear whether subjects who discontinued during the study conduct had a higher ris...

    Jonathan D. Adachi, Henry G. Bone, Nadia S. Daizadeh, Paula Dakin, Socrates Papapoulos, Peyman Hadji, Chris Recknor, Michael A. Bolognese, Andrea Wang, Celia J. F. Lin, Rachel B. Wagman and Serge Ferrari

    BMC Musculoskeletal Disorders 2017 18:174

    Published on: 27 April 2017

  12. Research article

    Silent progression in patients with rheumatoid arthritis: is DAS28 remission an insufficient goal in RA? Results from the German Remission-plus cohort

    Remission is arguably the ultimate therapeutic goal in rheumatoid arthritis (RA). Applying modern strategies, clinical remission can be achieved in a substantial number of patients with early RA (ERA). Even in...

    Philipp Sewerin, Stefan Vordenbaeumen, Annika Hoyer, Ralph Brinks, Christian Buchbender, Falk Miese, Christoph Schleich, Sabine Klein, Matthias Schneider and Benedikt Ostendorf

    BMC Musculoskeletal Disorders 2017 18:163

    Published on: 19 April 2017

  13. Research article

    Compliance and persistence with oral bisphosphonates for the treatment of osteoporosis in female patients with rheumatoid arthritis

    Poor adherence with oral bisphosphonates (BPs) can mitigate their therapeutic benefit for osteoporosis and is a significant clinical burden. Most previous studies regarding adherence with oral BPs have focused...

    Ji-Heh Park, Eun-Kyoung Park, Dong-Wan Koo, Shinwon Lee, Sun-Hee Lee, Geun-Tae Kim and Seung-Geun Lee

    BMC Musculoskeletal Disorders 2017 18:152

    Published on: 11 April 2017

  14. Research article

    Effect of teriparatide (rh-PTH 1–34) versus bisphosphonate on the healing of osteoporotic vertebral compression fracture: A retrospective comparative study

    Teriparatide (recombinant human parathyroid hormone 1–34) is increasingly used for the treatment of severe osteoporosis because it stimulates bone formation and may potentially enhance fracture healing. The ob...

    Akira Iwata, Masahiro Kanayama, Fumihiro Oha, Tomoyuki Hashimoto and Norimasa Iwasaki

    BMC Musculoskeletal Disorders 2017 18:148

    Published on: 7 April 2017

  15. Research article

    Patient Endorsement of the Outcome Measures in Rheumatology (OMERACT) Total Joint Replacement (TJR) clinical trial draft core domain set

    A patient- and surgeon-Delphi-derived Outcome Measures in Rheumatology (OMERACT) draft core domain set for total joint arthroplasty (TJR) trials was recently developed. Our objective was to obtain further pati...

    Jasvinder A. Singh, Michelle Dowsey and Peter F. Choong

    BMC Musculoskeletal Disorders 2017 18:111

    Published on: 15 March 2017

  16. Case report

    Cementoma of the calcaneus: a case report

    The cementoma is a common disease of the dental root apex, which generally occurs in the maxilla and the mandible, but the cementoma occurring in the long bone is rare. Moreover, the incidence of cementoma in ...

    Xiaona Li, Zhigang Peng, Mahrukh Latif, Abhinav Kumar, Wei Chen and Zekun Zhang

    BMC Musculoskeletal Disorders 2017 18:103

    Published on: 14 March 2017

  17. Research article

    Does rheumatoid synovitis activity vary during the day? Evaluation with color doppler sonography

    Clinical symptoms of rheumatoid arthritis (RA) improve in the course of the day, as can synovitis activity, reported via doppler ultrasound (US). The aim of the study was to establish whether the Color Doppler...

    Hakim Lazaar, Agnes Lhoste-Trouilloud, Bruno Pereira, Marion Couderc, Sylvain Mathieu and Martin Soubrier

    BMC Musculoskeletal Disorders 2017 18:98

    Published on: 4 March 2017

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