Chronic low back pain patient groups in primary care – A cross sectional cluster analysis
© Viniol et al.; licensee BioMed Central Ltd. 2013
Received: 4 March 2013
Accepted: 24 September 2013
Published: 16 October 2013
Due to the heterogeneous nature of chronic low back pain (CLBP), it is necessary to identify patient groups and evaluate treatments within these groups. We aimed to identify groups of patients with CLBP in the primary care setting.
We performed a k-means cluster analysis on a large data set (n = 634) of primary care patients with CLBP. Variables of sociodemographic data, pain characteristics, psychological status (i.e., depression, anxiety, somatization), and the patient resources of resilience and coping strategies were included.
We found three clusters that can be characterized as “pensioners with age-associated pain caused by degenerative diseases”, “middle-aged patients with high mental distress and poor coping resources”, and “middle-aged patients who are less pain-affected and better positioned with regard to their mental health”.
Our results supported current knowledge concerning groups of CLBP patients in primary care. In particular, we identified a group that was most disabled and distressed, and which was mainly characterized by psychological variables. As shown in our study, pain-related coping strategies and resilience were low in these patients and might be addressed in differentiating treatment strategies. Future studies should focus on the identification of this group in order to achieve effective treatment allocation.
German Clinical Trial Register DRKS00003123
KeywordsSubgroups Chronic low back pain Primary care
Chronic pain syndromes, especially chronic low back pain (CLBP) is one of the most prevalent diseases in Western populations  and is one of the most common reasons for primary care consultations . CLBP is associated with a high burden of disease with respect to health care costs and patients’ quality of life .
Current treatment recommendations emphasize a multidisciplinary approach for chronic lower back pain (CLBP) treatment . This therapy approach is effective, but often unrealistic as it is organizationally challenging, expensive, and cannot be made accessible to all CLBP patients .
A possible solution could be considering whether every CLBP patient needs the multidisciplinary treatment. Considering the heterogeneous and multifactorial nature of chronic pain patients, it might be necessary to differentiate the main characteristics of patient groups and evaluate individual treatment approaches .
Several attempts have been made to identify groups of pain patients. Studies are typically based on single dimensions such as traditional psychological measures (e.g., the Minnesota Multiphasic Personality Inventory or the Symptom Checklist-90-R) , pain expression , physical performance , patient perceived etiology , and psychophysiological responses . Multifactorial analyses usually study the impact of psychosocial characteristics in conjunction with pain-related fear [12, 13], emotional distress [14, 15], behavioral response [16, 17], or other psychosocial and behavioral characteristics . These studies are driven by prognostic risk factors; none focuses on protective factors like coping strategies and self-efficacy, which influence chronic pain in a positive way.
We aimed to identify groups of patients with CLBP in the primary care setting. For group analyses, we considered pain characteristics, common psychological characteristics (i.e., depression, anxiety, somatization), and also included patient resources like resilience and coping strategies, which might contribute to future recommendations for CLBP patient counseling.
Our data referred to the cross sectional baseline analysis of a 12-month cohort study that identified risk factors and protective factors of pain generalization in primary care CLBP patients. A detailed study protocol has been published elsewhere .
This project is part of the research consortium LOGIN “Localized and Generalized Musculoskeletal Pain: Psychobiological Mechanisms and Implications for Treatment”, funded by the German Federal Ministry of Education and Research.
During a 5-month period, fifty-eight general practitioners (evenly distributed in the northern region of Hessen in Germany) consecutively enrolled all eligible patients consulting for CLBP as a primary or secondary consulting reason (inclusion criteria). The symptom “chronic low back pain” was defined as back pain below the costal margin and above the inferior gluteal folds (with or without pain radiation), which had started at least three months prior and continued during most days (i.e., more than 50%) in the last three months. Patients under 18 years, pregnant women, and persons with an insufficient understanding of the German language or severe cognitive impairments (e.g., dementia) were excluded from the study.
Patients who gave their informed consent were asked to complete a questionnaire directly after the consultation or at home. During the recruitment period, trained clinical monitors conducted two random quality control audits of the GPs’ performance.
To explore descriptive characteristics, the questionnaire included the following physical and psychological parameters (for detailed information please see Viniol et al. ).
Pain characteristics and sociodemographic data
To evaluate the number of different pain areas, we measured pain localization with the “body pain drawing model” proposed by Pfau et al. . Pain anamnesis and sociodemographic data were determined with the “German Pain Questionnaire”, the official pain questionnaire of the German Association for the Study of Pain . We used the following DGSS modules: duration, characteristics, course of pain, sociodemographic data, health care utilization, and medication.
We used the three-item social support subscale from the West Haven-Yale Multidimensional Pain Inventory (WHYMPI) to explore the partner’s reaction in response to patient’s pain (internal consistency of the subscales: α = 0.63-0.90) [22, 23].
The severity of chronic pain was measured by the German translation of von Korff’s Graded Chronic Pain questionnaire (GCP) . Severity is computed from “pain intensity” and “pain-related disability” (internal consistency of subscales: α = 0.68-0.88) .
Using the Self-Administered Comorbidity Questionnaire (SACQ), we asked the patients about 14 common medical conditions: high blood pressure, heart disease, asthma, chronic obstructive pulmonary disease, ulcer/stomach disease, diabetes, high blood lipid level, kidney disease, osteoarthritis/degenerative arthritis, rheumatoid arthritis, osteoporosis, cancer disease, depression, other psychiatric diseases [26, 27].
Psychological parameters and patient resources
Psychosomatic symptoms were measured with the somatization subscale of the Symptom Checklist 90-Revised (SCL-90-R), a commonly used psychological status symptom inventory for psychopathology (internal consistency: α = 0.81) .
Coping resources for back pain were evaluated by the FBR (Fragebogen zu Bewältigungsressourcen bei Rückenschmerzen) questionnaire from Tamcam et al. .
We performed k-means cluster analyses generalized to all scales of measurement with squared euclidean distances . The k-means procedure identifies relatively homogenous groups while maximizing the variability between clusters. Variables with mixed scaling can be handled in cluster analysis [34, 35]. Calculations were done with ALMO 15 (http://www.almo-statistik.de), which includes a k-means algorithm that is able to handle the different scalings of our variables and the large sample size. This program provides statistical measures to evaluate the appropriateness of a cluster solution (F-value, eta2) .
Cluster analysis is an iterative process looking for the most relevant variables adding to an interpretable solution [36, 37]. Therefore, we ran several analyses for selection of variables, based on a variable-specific eta2 < 0.05. Accordingly, the following variables were excluded: gender, living with a partner, applied for pension, pain distribution, medication, WHYMPI – social support scale, education level, kind of job, time of pain. We attached special importance to certain individual variables (number of pain areas, therapeutic strategies, consultations, operations) so that they were included irrespective of their eta2.
The study was approved by the local ethics commission of Philipps University of Marburg, Germany (Ethik: 11.06.2010, AZ 88/10) and is in accordance with the Declaration of Helsinki.
Fifty-eight GPs with various practice characteristics (i.e., size, locations, and organizational structures) participated in the study. During the five-month recruitment period, they identified 746 eligible patients. Of these, 655 patients agreed to participate. A total of 647 subjects were analyzed; 8 patients were excluded because they did not report lower back pain in the pain drawing.
Total group characteristics
Sociodemographic data of the analyzed patients (n = 634)
Sex [no. (%)] n = 634
Age [mean: years (SD)] n = 634
Nationality [no. (%)] n = 619
Marital status [no. (%)] n = 634
Living with a partner [no. (%)] n = 611
Persons at household [no. (%)] n = 605
> 4 persons
Level and years of education [no. (%)] n = 632
Employment status [no. (%)] n = 631
Working (full or part-time)
Reasons for not working [no. (%)] n = 306
First time of back pain [no (%)] n = 634
Since < 1 year
Since 1-2 years
Since 2-5 years
Since 5-10 years
Since > 10 years
Description of cluster modeling
A three-cluster solution resulted in an Fmax-value of 76.16 and an eta2 of 0.191, meaning that 19.1% of the variance can be explained by this partitioning and can be considered as a cluster solution with acceptable quality criteria [34, 37, 38].
Contribution of classification variables to the separation of cluster (n = 634)
Variable specific eta2
Number of persons at household
- Working (full or part-time)
Reasons for not working
- Keeping house
Days on sick leave
Degree of disability
Number of pain areas
Index of the graded chronic pain (von Korff)
Gut feeling: Will the pain get away?
Number of different therapeutic strategies
Number of consultations because of back pain/6 months
Number of operations because of back pain
Symptom check-list-90-R (Somatization)
Self-administered comorbidity questionnaire (SACQ)
- Psychological comorbidities*
- Musculoskeletal comorbidities **
- Other comorbidities ***
Brief resilience scale (RS-11)
Hospital anxiety and depression (HADS)
Coping resources of back pain (FBR)
- Emotional social support
- Practical help
- Exercise and relaxation
- Hobby and enjoyment
- Cognitive strategies
Description of clusters
Characterization of the three clusters of CLBP patients (n = 634)
n = 179
n = 200
n = 255
Age [years: mean (SD)]
Persons at household [mean (SD)]
Employment status [no. (%)]
- Working (full or part-time)
Reasons for not working [no. (%)]
- Keeping house
Days on sick leave of the employed participants [mean (SD)]
Degree of disability [no. (%)]
Number of pain areas [mean (SD)]
Index of the graded chronic pain (von Korff) [no (%)]
Symptom check-list-90-R (Somatization) [mean (SD)]
Self-administered comorbidity questionnaire (SACQ) [no (%)]
- Psychological comorbidities*
- Musculoskeletal comorbidities**
- Other comorbidities***
Brief resilience scale (RS-11) [mean (SD)]
Hospital anxiety and depression (HADS) [mean (SD)]
Coping resources of back pain (FBR) [mean (SD)]
- Emotional social support
- Practical help
- Exercise and relaxation
- Hobby and enjoyment
- Cognitive strategies
Gut feeling: Will the pain get away? [no (%)]
Number of different therapeutic strategies [mean (SD)]
Number of consultations because of back pain / 6 months [mean (SD)]
Number of operations because of back pain [mean (SD)]
Cluster 1 - “pensioners with age-associated pain caused by degenerative diseases”
(n = 179, 28.2% of all patients) comprised mainly retired persons with an average age of 68.2 years (SD 8.6; age range: 42-88 years). Patients in this cluster suffered from a medium pain severity. In most cases, they had musculoskeletal and other chronic cardiovascular/pulmonary/stomach diseases. In comparison to the other cluster groups, cluster 1 scored highest regarding perceived efficacy of coping resources and mental disorders. Furthermore, patients in cluster 1 were optimistic with regard to their pain prognoses.
Cluster 2 - “middle-aged patients with high mental distress and poor coping resources”
(n = 200, 31.5% of all patients) consisted of middle-aged patients (mean 57.8 years, SD 13.1; age range: 26-87 years) with only 44.2% employed. Most unemployed patients were pensioners due to disability (72.6%). Remaining unemployed patients were either keeping house (17.7%) or seeking work (8.8%). Patients from cluster 2 had the most pronounced pain (highest rate of high pain severity and number of pain areas) and a high rate of pain-related disability. In comparison to the other clusters, patients in this cluster had more psychological distress (highest rate of the psychological comorbidities anxiety, depression, and symptoms of somatization). Furthermore, they had the worst resilience and the least efficient coping resources. They were high health care utilizers regarding the number of consultations and operations. We called them “middle-aged patients with high mental distress and poor coping resources”.
Cluster 3 - “middle-aged patients who are less pain-affected and better positioned with regard to their mental health”
(n = 255, 40.2% of all patients) was also comprised of middle-aged (mean 46.8 years; SD 10.3; age range: 20-73years), but mostly working (87.1%) patients. In comparison to the second cluster, they were less pain affected, had fewer comorbidities and showed a better mental health (lower rates of anxiety, depression, and psychological comorbidities). Resilience was higher and coping resources were more pronounced than in patients belonging to cluster 2. In addition, they rarely required health care.
Main characteristics of the three clusters
Age on average
Working status of the majority
Severity of pain
Mental disorders (somatization, anxiety, depression, psychological comorbidities*)
Resources (resilience, coping)
Health care utilization
We performed a k-means cluster analysis on a large data set of primary care patients with chronic low back pain. We found three clusters that can be characterized as “pensioners with age-associated pain caused by degenerative diseases”, “middle-aged patients with high mental distress and poor coping resources”, and “middle-aged patients who are less pain-affected and better positioned with regard to their mental health”.
Several researchers have stated the need to identify patient groups that could serve as target groups for effective treatment strategies . Turk et al. identified three groups of chronic pain patients by the WHYMPI [22, 39]. The first group, “dysfunctional patients”, corresponds to patients with high pain severity, a low activity level, marked interference with everyday life due to pain, high affective distress, and low perception of life control. The second group, “adaptive copers”, is characterized by a lower pain severity, a higher activity level, lower interference and affective distress, and higher life control. The third group, “interpersonally distressed”, features middle pain severity, general activity, interference and affective distress, and lower social support than the other two groups.
Shaw et al. identified four groups of patients with acute work-related back pain based on disability risk factors (pain, depressive mood, fear avoidance beliefs, work inflexibility, and poor expectations for recovery) . Group one consists of patients who are most affected by pain, concerned with high physical demands at work. This group resembles the “fear avoidance” category and shows low expectations of returning to work. Group two is characterized by a high rate of emotional distress and above average pain intensity. Patients in group three are identified by a high degree of concern about job placement. Finally, patients from group four show low risk factors for disability. They have positive expectations for workplace accommodation and returning to normal work.
Boersma et al. identified groups of acute and subacute spinal pain patients with regard to their risk for permanent pain or disability . Their group profiles “fear-avoidant”, “distressed fear-avoidant”, “low risk” and “low risk depressed mood” are comparable to the results of Shaw et al.
Even though the included variables and patient populations (e.g., acute vs. chronic pain, low vs. no low back pain, different settings) of the aforementioned studies differ, they all have one aspect in common: All analyses revealed one patient group which seems most distressed and shows above average mental distress and high pain severity. In this way, mental health status seems to be a key differential factor.
The primary care setting comprises a high prevalence of older, often multimorbid patients and many chronic diseases. Therefore, groups identified in different settings might not be relevant for general practice . Even though we could confirm the presence of middle-aged groups with minor and major psychosocial distress, further studies are required; diagnostic studies to identify these groups and treatment studies, which would prove effectiveness of group-specific treatments.
Hill et al. developed the STarT Back tool for the primary care setting . The tool classifies patients with low back pain (LBP) into three groups based on nine questions referring to potentially modifiable physical and psychological prognostic indicators for persistent, disabling symptoms. Patients are categorized as “low risk”, “medium risk”, and “high risk” for future disabling LBP. However, the studies from Hill et al. included patients with acute and chronic LBP. Our study focused only on patients with chronic LBP.
Our study is subject to selection bias. GPs may have subconsciously preferred to recruit special cases (e.g., patients with higher disease severity or special personality), or forgotten to recruit patients due to high workload. Furthermore, some patients may have refused to participate in our study due to the long questionnaire, especially considering that our study population included a large proportion of older people with age-associated mental deficiencies. These factors might reduce the external validity of our results. In general, a limitation of cluster analysis is that the results depend on the input variables .
Since the less pain-affected patients of cluster three (average age: 46.8 years) are younger than the more pain-affected patients of cluster two (average age: 57.8 years), it is possible that younger patients from the third cluster will move to the second cluster as they age. This is especially likely because increased age is a proven risk factor for increased pain outcomes (e.g., transition from localized to widespread pain) . We should soon be able to prove this hypothesis using follow-up data from our cohort study.
Our results supported current knowledge concerning groups of CLBP patients in primary care. This knowledge could be the starting point for developing a group-specific therapy for general practitioners.
For the group “pensioners with age-associated pain caused by degenerative diseases”, a therapeutic orientation aligned with the guideline “pain of older people” [46, 47] would be appropriate. It involves evidence-based treatment approaches individually adapted to older people and their comorbidities.
The group “patients of an employable age with high mental distress and poor coping resources” should receive multimodal pain therapy with a particular focus on psychotherapy to improve coping resources and resilience. With regard to the fact that mental disorders, especially depression, are the most decisive cost factor of chronic pain , it is particularly important to treat them in an effective manner.
For the group “patients of an employable age who are less pain-affected and better positioned with regards to their mental conditions”, a general practitioner-based, time-contingent monitoring should be indicated. It should be planned independent of pain exacerbations and should be conducted according to the bio-psycho-social model of pain.
Next step of our research will be to develop a therapy study which evaluates the efficacy of group-specific therapy approaches.
Chronic low back pain
West haven-uyale multidimensional pain inventory
Graded chronic pain
Self-administered comorbidity questionnaire
Symptom checklist 90-revised
Hospital anxiety and depression scale
Fragebogen zu Bewältigungsressourcen bei Rückenschmerzen (questionnaire for assessing coping resources for back pain)
We thank our study nurses Muazzez Ilhan and Marion Herz-Schuchhardt for their excellent work. Furthermore, thank you to all participating doctors and patients. We also would like to thank Juliette Rautenberg for providing English-language editing, improving the precision and fluency of the manuscript.
This work is funded by the German Federal Ministry of Education and Research.
- Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D: Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain. 2006, 10: 287-333. 10.1016/j.ejpain.2005.06.009.View ArticlePubMed
- Friessem CH, Willweber-Strumpf A, Zenz MW: Chronische Schmerzen in deutschen Facharztpraxen. Die aktuelle Inanspruchnahme des ambulanten Gesundheitssystems anhand der Prävalenz von Schmerzen. Schmerz. 2010, 24: 501-507. 10.1007/s00482-010-0958-3.View ArticlePubMed
- Andersson GB: Epidemiological features of chronic low-back pain. Lancet. 1999, 354: 581-585. 10.1016/S0140-6736(99)01312-4.View ArticlePubMed
- Bundesärztekammer (BÄK), Kassenärztliche Bundesvereinigung (KBV), Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF): Nationale Versorgungsleitlinie Kreuzschmerz – Langfassung. [National guideline for low back pain - long version]. Version 1.2. 2011, Berlin
- Dietl MKD: Versorgungssituation in der Schmerztherapie in Deutschland im internationalen Vergleich hinsichtlich Über-, Unter- oder Fehlversorgung: HTA-Bericht. 2011, Köln: [Health care services of pain therapy in Germany – an international comparison regarding to over-, undersupply and inappropriate health care services]
- Wand B, O’Connell N: Chronic non-specific low back pain – sub-groups or a single mechanism?. BMC Musculoskelet Disord. 2008, 9: 11-10.1186/1471-2474-9-11.PubMed CentralView ArticlePubMed
- Schwimmer G, Robinson M, Geissner M: Relationship of MMPI cluster types, pain coping strategy, and treatment outcome. Clin J Pain. 1992, 2: 131-137.View Article
- Keefe FJ, Bradley LA, Crisson JE: Behavioral assessment of low back pain: identification of pain behavior subgroups. Pain. 1990, 40: 153-160. 10.1016/0304-3959(90)90066-M.View ArticlePubMed
- Hutten MM, Hermens HJ, Zilvold G: Differences in treatment outcome between subgroups of patients with chronic low back pain using lumbar dynamometry and psychological aspects. Clin Rehabil. 2001, 15: 479-488. 10.1191/026921501680425207.View ArticlePubMed
- Waylonis GW, Perkins RH: Post-traumatic fibromyalgia. A long-term follow-up. Am J Phys Med Rehabil. 1994, 73: 403-412. 10.1097/00002060-199411000-00005.View ArticlePubMed
- Thieme K, Rose U, Pinkpank T, Spies C, Turk DC, Flor H: Psychophysiological responses in patients with fibromyalgia syndrome. J Psychosom Res. 2006, 61: 671-679. 10.1016/j.jpsychores.2006.07.004.View ArticlePubMed
- Boersma K, Linton SJ: Expectancy, fear and pain in the prediction of chronic pain and disability: a prospective analysis. Eur J Pain. 2006, 10: 551-557. 10.1016/j.ejpain.2005.08.004.View ArticlePubMed
- Fritz JM, George SZ, Delitto A: The role of fear-avoidance beliefs in acute low back pain: relationships with current and future disability and work status. Pain. 2001, 94: 7-15. 10.1016/S0304-3959(01)00333-5.View ArticlePubMed
- Boersma K, Linton SJ: Psychological processes underlying the development of a chronic pain problem: a prospective study of the relationship between profiles of psychological variables in the fear-avoidance model and disability. Clin J Pain. 2006, 22: 160-166. 10.1097/01.ajp.0000159582.37750.39.View ArticlePubMed
- Pincus T, Burton AK, Vogel S, Field AP: A systematic review of psychological factors as predictors of chronicity/disability in prospective cohorts of low back pain. Spine (Phila Pa 1976). 2002, 27: 109-120. 10.1097/00007632-200203010-00017.View Article
- Thieme K, Flor H, Turk DC: Psychological pain treatment in fibromyalgia syndrome: efficacy of operant behavioural and cognitive behavioural treatments. Arthritis Res Ther. 2006, 8: 121-10.1186/ar2010.View Article
- Verra ML, Angst F, Brioschi R, Lehmann S, Keefe FJ, Staal JB, de Bie RA, Aeschlimann A: Does classification of persons with fibromyalgia into Multidimensional Pain Inventory subgroups detect differences in outcome after a standard chronic pain management program?. Pain Res Manag. 2009, 14: 445-453.PubMed CentralPubMed
- Turk DC, Okifuji A, Sinclair JD, Starz TW: Pain, disability, and physical functioning in subgroups of patients with fibromyalgia. J Rheumatol. 1996, 23: 1255-1262.PubMed
- Viniol A, Jegan N, Leonhardt C, Strauch K, Brugger M, Barth J, Baum E, Becker A: Study protocol: transition from localized low back pain to chronic widespread pain in general practice: identification of risk factors, preventive factors and key elements for treatment - A cohort study. BMC Musculoskelet Disord. 2012, 13: 77-10.1186/1471-2474-13-77.PubMed CentralView ArticlePubMed
- Pfau DB, Rolke R, Nickel R, Treede R, Daublaender M: Somatosensory profiles in subgroups of patients with myogenic temporomandibular disorders and fibromyalgia syndrome. Pain. 2009, 147: 72-83. 10.1016/j.pain.2009.08.010.View ArticlePubMed
- Deutsche Gesellschaft zum Studium des Schmerzes (DGSS): Deutscher Schmerzfragebogen. Version 2012.2. 2012, Colone
- Kerns R, Turk D, Rudy T: The West Haven-Yale multidimensional pain inventory (WHYMPI). Pain. 1985, 23: 345-356. 10.1016/0304-3959(85)90004-1.View ArticlePubMed
- Flor H, Rudy TE, Birbaumer N, Streit B, Schugens MM: Zur Anwendbarkeit des West Haven-Yale Multidimensional Pain Inventory im deutschen Sprachraum. Daten zur Reliabilität und Validität des MPI-D. Schmerz. 1990, 4: 82-87. 10.1007/BF02527839.View ArticlePubMed
- von Korff M, Dworkin S, Resche L: Graded chronic pain status an epidemiologic evaluation. Pain. 1990, 40: 179-291.View Article
- Klasen BW, Hallner D, Schaub C, Willburger R, Hasenbring M: Validation and reliability of the German version of the chronic pain grade questionnaire in primary care back pain patients. Psychosoc Med. 2004, 1: 7-
- Sangha O, Stucki G, Liang MH, Fossel AH, Katz JN: The self-administered comorbidity questionnaire. A new method to assess comorbidity for clinical and health services research. Arthritis Rheum. 2003, 49: 156-163. 10.1002/art.10993.View ArticlePubMed
- Hüppe A, Raspe H: Amplifizierte Rückenschmerzen und Komorbidität in der Bevölkerung. Der Schmerz. 2009, 23: 275-283.PubMed
- Franke G, Stäcker K: Reliabilität und Validität der Symptom-Check-Liste (SCL-90-R; Derogatis 1986) bei Standardreihenfolge versus inhaltshomogener Itemblockbildung. Diagnostica. 1995, 41: 349-373.
- Zigmont AS, Snaith RP: The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983, 67: 361-370. 10.1111/j.1600-0447.1983.tb09716.x.View Article
- Herrmann C: International experiences with the hospital anxiety and depression scale – a review of validation data and clinical results. J Psychosom Res. 1997, 42: 17-41. 10.1016/S0022-3999(96)00216-4.View ArticlePubMed
- Tamcan Ö, Bantli S, Abel T, Barth J: Coping resources for back pain. a new assessment tool for clinical practice. Zeitschrift für Medizinische Psychologie. 2010, 19: 21-29.
- Wagnild GM, Young HM: Development and psychometric evaluation of the resilience scale. J Nurs Meas. 1993, 1: 165-178.PubMed
- Schumacher J, Leppert K, Gunzelmann T, Strauß B, Brähler E: Die Resilienzskala – Ein Fragebogen zur Erfassung der psychischen Widerstandsfähigkeit als Personmerkmal. Z Klin Psychol Psychiatr Psychother. 2005, 53: 16-39.
- Bacher J: Clusteranalyse. Anwendungsorientierte Einführung in Klassifikationsverfahren [Cluster analysis. Practical introduction in classification measures]. 2010, Oldenbourg: Munich
- Schendera CF: Clusteranalyse mit SPSS: Mit Faktorenanalyse. [Cluster analysis with SPSS: including factor analysis]. 2009, Oldenbourg: Munich
- Everitt BS: Cluster analysis. 2001, London: Arnold
- Kaufman L: Finding groups in data. An introduction to cluster analysis. 2005, Hoboken: Wiley-Blackwell Publishing Ltd
- Jaccard J: Statistics for the behavioral sciences. 2009, Belmont: Wadsworth
- Turk DC, Rudy TE: Toward an empirically derived taxonomy of chronic pain patients: integration of psychological assessment data. J Consult Clin Psychol. 1988, 56: 233-238.View ArticlePubMed
- Shaw WS, Pransky G, Patterson W, Linton SJ, Winters T: Patient clusters in acute, work-related back pain based on patterns of disability risk factors. J Occup Environ Med. 2007, 49: 185-193. 10.1097/01.jom.0000254205.47334.c3.View ArticlePubMed
- Boersma K, Linton SJ: Screening to identify patients at risk: profiles of psychological risk factors for early intervention. Clin J Pain. 2005, 21: 38-43. 10.1097/00002508-200501000-00005.View ArticlePubMed
- Hay EM, Dunn KM, Hill JC, Lewis M, Mason EE, Konstantinou K, Sowden G, Somerville S, Vohora K, Whitehurst D, Main CJ: A randomised clinical trial of subgrouping and targeted treatment for low back pain compared with best current care. The STarT Back Trial Study Protocol. BMC Musculoskelet Disord. 2008, 9: 58-10.1186/1471-2474-9-58.PubMed CentralView ArticlePubMed
- Hill JC, Dunn KM, Lewis M, Mullis R, Main CJ, Foster NE, Hay EM: A primary care back pain screening tool: identifying patient subgroups for initial treatment. Arthritis Rheum. 2008, 59: 632-641. 10.1002/art.23563.View ArticlePubMed
- Morrison DG: Measurement problems in cluster analysis. Management Science. 1967, 13: 775-780.View Article
- Larsson B, Bjork J, Borsbo B, Gerdle B: A systematic review of risk factors associated with transitioning from regional musculoskeletal pain to chronic widespread pain. Eur J Pain. 2012, 8: 1084-1093.View Article
- AGS Panel on Persistent Pain in Older Persons: The management of persistent pain in older persons. J Am Geriatr Soc. 2002, 50: 205-224.View Article
- Hadjistavropoulos T: Self-management of pain in older persons: helping people help themselves. Pain Med. 2012, 13: 67-71.View Article
- Becker A: Health economics of interdisciplinary rehabilitation for chronic pain: does it support or invalidate the outcomes research of these programs?. Curr Pain Headache Rep. 2012, 16: 127-132. 10.1007/s11916-012-0249-z.View ArticlePubMed
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2474/14/294/prepub
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.