Solitary osteochondroma of the twelfth rib with intraspinal extension and cord compression in a middle-aged patient
© Shim et al; licensee BioMed Central Ltd. 2012
Received: 15 July 2011
Accepted: 13 April 2012
Published: 13 April 2012
Osteochondroma is a disease of growing bone and thus typically presents in younger patients. It has rarely been described in middle-aged and elderly patients. Data on the occurrence of osteochondroma show that the reported incidence of costal osteochondroma is very low. Moreover, costal osteochondroma arising at the costovertebral junction with neural foraminal extension and spinal cord compression is extremely rare.
This study reports the case of a 58-year-old patient with a solitary osteochondroma of the 12th rib with intraspinal extension and spinal cord compression. The clinical history, plain radiographs, computed tomography (CT), magnetic resonance imaging, and pathologic findings of the reported patient have been reviewed. The relevant medical literature has also been reviewed. The patient was treated with surgery for complete tumour excision to avoid tumour recurrence. After surgery, the patient's symptoms improved. An additional CT scan obtained at 1 year after surgery did not show any evidence of recurrence.
This patient is the oldest patient reported to have this rare form of costal osteochondroma. The age of the patient and the erosion of the adjacent bones raised clinical suspicion of malignancy; therefore, surgical management involved complete tumour excision with thoracolumbar fixation and fusion.
Osteochondromas are the most common benign tumours of the bone and may present as either a solitary lesion or as multiple lesions [1, 2]. Solitary lesions are most common, but presentations of multiple lesions, usually with autosomal dominant inheritance, are termed hereditary multiple exostoses (HMEs) . These tumours commonly occur in the long bones, but seldom affect ribs [3, 4]. Only 1.5% of all osteochondromas are costal osteochondromas, and spinal cord compression due to a tumour arising from the head of a rib is even more rare [3, 4].
We report a case that is unusual in many aspects such as the site of tumour origin within the rib; associated myelopathic symptoms; occurrence in a middle-aged patient; and the erosion and fusion of the vertebral pedicle, facet, and body due to tumour extension. Extension of the tumour necessitated total pediculectomy of T12, total facetectomy of T12-L1, and partial unilateral vertebrectomy of T12 with thoracolumbar fixation and fusion.
A 58-year-old man presented with a 3-month history of right lower extremity weakness and numbness. He also reported progressive gait disturbance of 1-month duration. He denied bowel and bladder incontinence and sexual dysfunction. There was no medical or family history of neurologic dysfunction or bony tumour. Neurologic examination showed profound weakness, decreased pinprick sensation, and hyperreflexia of his right lower extremity. Right ankle clonus and positive Babinski response were also elicited.
Summary of the 7 previously reported cases of costal osteochondroma causing spinal cord compression
Osteochondroma is a disease of growing bone, and thus typically presents in younger patients . Tumour growth occurs early during childhood and usually arrests after puberty when the epiphysis closes . Osteochondroma has rarely been described in middle-aged and elderly patients [10, 11]. The pathophysiologic mechanisms underlying late-onset disease are not clearly understood. Some researchers believe that malignant transformation may abruptly increase the size of the lesion, thereby resulting in symptoms in older patients [12, 13]. In the present case, the patient was 58 years old and is the oldest reported patient with costal osteochondroma. Careful histopathologic examination indicated the absence of malignancy.
Although the location of the bony portion of the osteochondroma can be reliably determined using multiplanar CT reconstruction, the exact size of the tumour may be underestimated because the cartilage cap of the tumour is not detectable by CT [3, 4]. MR imaging is the best radiologic modality for evaluating the hyaline cartilage cap. The non-mineralized portions of the cartilage cap have high water content, resulting in intermediate-to-low signal intensity on T1-weighted images and high signal intensity on T2-weighted MR images. These features allow for accurate measurement of the thickness of the cartilage cap and distinction from overlying muscle on MR images . In this case, the unique curvilinear high-signalintensity region covering the tumour, seen on axial T2-weighted images, represents the cartilage cap, which led to accurate preoperative diagnosis.
Malignant transformation, usually into a chondrosarcoma, occurs in approximately 1% of solitary osteochondromas and 10% of HMEs [9, 12]. A sudden increase in lesion size or the development of new-onset pain suggests malignant transformation [12, 13]. Bess et al.  emphasised that preoperative radiographic evaluation should consist of MR and CT imaging in order to provide optimal information about the lesion, which aids in surgical planning . Radiologic findings may show consistent growth of exostoses after closure of the growth plate, alterations in surface delineation in comparison with previous radiographic studies, internal lytic areas, erosion or destruction of adjacent bones, and the presence of soft tissue masses containing scattered or irregular calcifications [15, 16]. The size of the cartilaginous cap is the best indicator of malignancy . MR imaging results showing a cartilage cap thickness exceeding 2 cm in adults and 3 cm in children should raise the suspicion of malignancy . The use of gadolinium diethylenetriamine-pentacetate (Gd-DTPA)-enhanced MR imaging is an effective procedure for obtaining a differential diagnosis between malignant and benign lesions . Generally, osteochondromas do not show contrast enhancement, but mild enhancement may be observed within the marrow . In this case, Gd-DTPA-enhanced MR imaging was used, and the images did not show contrast enhancement. Because asymptomatic solitary osteochondromas have a low rate of malignant transformation, they can be followed up conservatively [20, 21]. When the tumour causes pain or neurologic complications because of compression, or when the diagnosis is uncertain, the tumour should be completely excised to avoid tumour recurrence [22, 23]. For any recurrence, the possibility of malignant transformation of the osteochondroma or of a low-grade chondrosarcoma that was initially poorly classified should be anticipated . Because of the age of the patient and the presence of erosion into adjacent bones, the clinical suspicion for malignancy was high in this case. A surgical strategy for complete tumour excision was carefully planned to prevent tumour recurrence. As osteochondromas may pass through the neural foramen and lead to cord compression, the surgical approach should include decompression surgery such as laminectomy and/or facetectomy at the corresponding level . If additional facetectomy is performed to remove the foramen and/or extraforaminal component, iatrogenic instability and kyphosis may occur during the follow-up period. In this case, hemilaminectomy of the right side of T12 and total facetectomy on the right side of T12-L1 provided wide exposure of the intraspinal and extraforaminal tumour originating from the rib. Additionally, because pressure erosions, suggestive of a slow-growing tumour, were noted in the adjacent bony structures, a total pediculectomy and partial vertebrectomy on the right side of T12 were performed, accompanied by the partial removal of the right proximal 12th rib. Therefore, it was essential to perform posterior thoracolumbar fixation and fusion for stability. However, fixation and fusion were performed only on the contralateral (left) side to avoid disturbing the radiologic follow-up required for monitoring tumour recurrence. Plain dynamic films showed that bone fusion was achieved 6 months after surgery. Although CT did not show any recurrence at the 1-year follow-up, further clinical and radiologic follow-up is required for monitoring tumour recurrence.
The type of osteochondroma described in this case, which arose at the costovertebral junction with neural foraminal extension and spinal cord compression, is extremely rare. Only 7 such cases have been previously reported in the English-language literature. This is the first report of this form of rare costal osteochondroma occurring in a middle-aged patient and requiring surgical management involving complete tumour excision with thoracolumbar fixation and fusion. Malignancy remained a possibility throughout because of the patient's age and erosion of adjacent bones.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
The authors thank Jo Young Son and Hannah Lee for assistance in preparing this manuscript.
- Albrecht S, Crutchfield JS, SeGall GK: On spinal osteochondromas. J Neurosurg. 1992, 77: 247-252. 10.3171/jns.1992.77.2.0247.View ArticlePubMedGoogle Scholar
- Jose Alcaraz Mexia M, Izquierdo Nunez E, Santonja Garriga C, Maria Salgado Salinas R: Osteochondroma of the thoracic spine and scoliosis. Spine. 2001, 26: 1082-1085. 10.1097/00007632-200105010-00019.View ArticlePubMedGoogle Scholar
- Chazono M, Masui F, Kawaguchi Y, Hazama H, Ueda J, Saito S: Dumbbell-shaped osteochondroma of the fifth rib causing spinal cord compression. J Orthop Sci. 2009, 14: 336-338. 10.1007/s00776-008-1323-6.View ArticlePubMedGoogle Scholar
- Tang WM, Luk KD, Leong JC: Costal osteochondroma. A rare cause of spinal cord compression. Spine. 1998, 23: 1900-1903. 10.1097/00007632-199809010-00021.View ArticlePubMedGoogle Scholar
- Rao A, Abraham RG, Rajshekhar V: Osteochondroma of rib with neural foraminal extension and cord compression. Neurol India. 2007, 55: 428-429. 10.4103/0028-3886.33304.View ArticlePubMedGoogle Scholar
- Kane PJ, Coulthard A, Raghavan R, Jenkins A: Osteochondroma of the rib: an unusual cause of paraparesis. Surg Neurol. 1994, 41: 414-417. 10.1016/0090-3019(94)90037-X.View ArticlePubMedGoogle Scholar
- Natarajan M, Balakrishnan D, Srinivasan V: Solitary osteochondroma causing spinal cord compression. Int Surg. 1976, 61: 494-495.PubMedGoogle Scholar
- Twersky J, Kassner EG, Tenner MS, Camera A: Vertebral and costal osteochondromas causing spinal cord compression. Am J Roentgenol Radium Ther Nucl Med. 1975, 124: 124-128.View ArticlePubMedGoogle Scholar
- Brastianos P, Pradilla G, McCarthy E, Gokaslan ZL: Solitary thoracic osteochondroma: case report and review of the literature. Neurosurgery. 2005, 56: E1379-10.1227/01.NEU.0000159718.69601.AC. discussion E1379View ArticlePubMedGoogle Scholar
- Sakai D, Mochida J, Toh E, Nomura T: Spinal osteochondromas in middle-aged to elderly patients. Spine. 2002, 27: E503-E506. 10.1097/00007632-200212010-00017.View ArticlePubMedGoogle Scholar
- Yagi M, Ninomiya K, Kihara M, Horiuchi Y: Symptomatic osteochondroma of the spine in elderly patients. Report of 3 cases. J Neurosurg Spine. 2009, 11: 64-70. 10.3171/2009.3.SPINE0912.View ArticlePubMedGoogle Scholar
- Khosla A, Martin DS, Awwad EE: The solitary intraspinal vertebral osteochondroma. An unusual cause of compressive myelopathy: features and literature review. Spine. 1999, 24: 77-81. 10.1097/00007632-199901010-00019.View ArticlePubMedGoogle Scholar
- Sharma MC, Arora R, Deol PS, Mahapatra AK, Mehta VS, Sarkar C: Osteochondroma of the spine: an enigmatic tumor of the spinal cord. A series of 10 cases. J Neurosurg Sci. 2002, 46: 66-70. discussion 70PubMedGoogle Scholar
- Murphey MD, Choi JJ, Kransdorf MJ, Flemming DJ, Gannon FH: Imaging of osteochondroma: variants and complications with radiologic-pathologic correlation. Radiographics. 2000, 20: 1407-1434.View ArticlePubMedGoogle Scholar
- Bess RS, Robbin MR, Bohlman HH, Thompson GH: Spinal exostoses: analysis of twelve cases and review of the literature. Spine. 2005, 30: 774-780. 10.1097/01.brs.0000157476.16579.a2.View ArticlePubMedGoogle Scholar
- Porter DE, Emerton ME, Villanueva-Lopez F, Simpson AH: Clinical and radiographic analysis of osteochondromas and growth disturbance in hereditary multiple exostoses. J Pediatr Orthop. 2000, 20: 246-250.PubMedGoogle Scholar
- Quirini GE, Meyer JR, Herman M, Russell EJ: Osteochondroma of the thoracic spine: an unusual cause of spinal cord compression. AJNR Am J Neuroradiol. 1996, 17: 961-964.PubMedGoogle Scholar
- Woertler K, Lindner N, Gosheger G, Brinkschmidt C, Heindel W: Osteochondroma: MR imaging of tumor-related complications. Eur Radiol. 2000, 10: 832-840. 10.1007/s003300051014.View ArticlePubMedGoogle Scholar
- Ohtori S, Yamagata M, Hanaoka E, Suzuki H, Takahashi K, Sameda H: Osteochondroma in the lumbar spinal canal causing sciatic pain: report of two cases. J Orthop Sci. 2003, 8: 112-115. 10.1007/s007760300019.View ArticlePubMedGoogle Scholar
- Chatzidakis E, Lypiridis S, Kazdaglis G, Chatzikonstadinou K, Papatheodorou G: A rare case of solitary osteochondroma of the dens of the C2 vertebra. Acta Neurochir. 2007, 149: 637-638. 10.1007/s00701-007-1151-z.View ArticlePubMedGoogle Scholar
- Gurkanlar D, Aciduman A, Gunaydin A, Kocak H, Celik N: Solitary intraspinal lumbar vertebral osteochondroma: a case report. J Clin Neurosci. 2004, 11: 911-913. 10.1016/j.jocn.2004.02.013.View ArticlePubMedGoogle Scholar
- Arasil E, Erdem A, Yuceer N: Osteochondroma of the upper cervical spine. A case report. Spine. 1996, 21: 516-518. 10.1097/00007632-199602150-00021.View ArticlePubMedGoogle Scholar
- Lotfinia I, Vahedi P, Tubbs RS, Ghavame M, Meshkini A: Neurological manifestations, imaging characteristics, and surgical outcome of intraspinal osteochondroma. J Neurosurg Spine. 2010, 12: 474-489. 10.3171/2009.11.SPINE0980.View ArticlePubMedGoogle Scholar
- Gille O, Pointillart V, Vital JM: Course of spinal solitary osteochondromas. Spine. 2005, 30: E13-E19.View ArticlePubMedGoogle Scholar
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